| Literature DB >> 11591175 |
J W Cho1, Y W Jeong, K S Kim, J Y Oh, J C Park, J C Lee, W K Baek, S I Suh, M H Suh.
Abstract
TPA-treated HL-60 cells are mainly arrested in G1 by p21(WAF1) accumulation. We investigate the downstream changes following such accumulation. Increased p21(WAF1) is associated with CDK2 and CDK4. pRb is dephosphorylated in the presence of p21-CDK2/4 complexes, and the Rb-E2F1 complex increases after TPA treatment, whereas the Rb-HDAC1 complex decreases slightly. Our results suggest that increased p21(WAF1) is associated with CDK2/4, and that these complexes induce pRb dephosphorylation. In turn, hypophosphorylated pRb are mainly complexed with E2F1, but HDAC1 appears not to be a key component in this process.Entities:
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Year: 2001 PMID： 11591175 PMCID： PMC6495204 DOI： 10.1046/j.0960-7722.2001.00208.x
Source DB: PubMed Journal: Cell Prolif ISSN： 0960-7722 Impact factor: 6.831