UNLABELLED: Interleukin (IL)-7 is a critical cytokine regulating T-lymphocyte development, regeneration, and function. PURPOSE: This study analyzes the endogenous IL-7 production in HIV-infected patients receiving highly active antiretroviral treatment (HAART). METHOD: Plasma levels of IL-7 were measured by enzyme-linked immunosorbent assay (ELISA) in 11 patients with untreated advanced HIV disease, in 8 patients who successfully responded to HAART, and in 9 individuals with virological and immunological treatment failure. RESULTS: We found that in the patients with advanced HIV disease and no treatment IL-7 concentrations were elevated and were inversely related to both CD4 + and CD8 + T-cell counts. When IL-7 was assessed in treated patients, this cytokine was below the detection limit of the assay in all participants who responded to HAART. On the contrary, patients with evidence of HAART failure had increased concentrations of IL-7 that were comparable to those found in the untreated group with progressive disease. CONCLUSION: These data suggest that IL-7 may play a role in the immune reconstitution of T-cells during HIV infection, especially in the context of potent antiretroviral treatments.
UNLABELLED: Interleukin (IL)-7 is a critical cytokine regulating T-lymphocyte development, regeneration, and function. PURPOSE: This study analyzes the endogenous IL-7 production in HIV-infectedpatients receiving highly active antiretroviral treatment (HAART). METHOD: Plasma levels of IL-7 were measured by enzyme-linked immunosorbent assay (ELISA) in 11 patients with untreated advanced HIV disease, in 8 patients who successfully responded to HAART, and in 9 individuals with virological and immunological treatment failure. RESULTS: We found that in the patients with advanced HIV disease and no treatment IL-7 concentrations were elevated and were inversely related to both CD4 + and CD8 + T-cell counts. When IL-7 was assessed in treated patients, this cytokine was below the detection limit of the assay in all participants who responded to HAART. On the contrary, patients with evidence of HAART failure had increased concentrations of IL-7 that were comparable to those found in the untreated group with progressive disease. CONCLUSION: These data suggest that IL-7 may play a role in the immune reconstitution of T-cells during HIV infection, especially in the context of potent antiretroviral treatments.
Authors: Surender B Kumar; Cara E Rice; Danny A Milner; Nilsa C Ramirez; William E Ackerman; Victor Mwapasa; Abigail Norris Turner; Jesse J Kwiek Journal: AIDS Date: 2012-03-27 Impact factor: 4.177
Authors: Jessica N Hodge; Sharat Srinivasula; Zonghui Hu; Sarah W Read; Brian O Porter; Insook Kim; Joann M Mican; Chang Paik; Paula Degrange; Michele Di Mascio; Irini Sereti Journal: Blood Date: 2011-07-21 Impact factor: 22.113
Authors: Sallie R Permar; William J Moss; Judith J Ryon; Daniel C Douek; Mwaka Monze; Diane E Griffin Journal: J Virol Date: 2003-07 Impact factor: 5.103
Authors: Richard M Dunham; Barbara Cervasi; Jason M Brenchley; Helmut Albrecht; Amy Weintrob; Beth Sumpter; Jessica Engram; Shari Gordon; Nichole R Klatt; Ian Frank; Donald L Sodora; Daniel C Douek; Mirko Paiardini; Guido Silvestri Journal: J Immunol Date: 2008-04-15 Impact factor: 5.422
Authors: Jerome Kerzerho; Elizabeth J McIlvaine; Patricia Anthony; Wendy J Mack; Chia-Hao Wang; Toni Frederick; Eva Operskalski; Zhi Chen; Lena Al-Harthi; Alan Landay; Mary A Young; Phyllis C Tien; Michael Augenbraun; Howard D Strickler; Omid Akbari; Elizabeth T Golub; Gerald B Sharp; Andrea Kovacs Journal: J Acquir Immune Defic Syndr Date: 2016-02-01 Impact factor: 3.731