E T Lee1, M Lu, P H Bennett, H Keen. 1. Centre for American Indian Health Research and Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Centre, Oklahoma City 73190, USA.
Abstract
AIMS/HYPOTHESIS: This study compared the incidence of vascular disease in subjects with younger-onset diabetes from different ethnic groups. METHODS: The incidence of vascular disease endpoints has been studied in a sub-group (n = 994) of participants of the World Health Organization Multinational Study of Vascular Disease in Diabetes (WHO MSVDD) who had younger-onset diabetes (diagnosed before the age of 30 years). The study participants have been divided into European (n = 631), Asian (n = 84) and American Indian (n = 91) cohorts. RESULTS: For Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus, American Indian men had a higher incidence of lower-extremity amputation and renal failure than the other cohorts, whereas European women had a higher incidence of angina than other cohorts. American Indians also had a higher incidence of any retinopathy, clinical proteinuria and albuminuria than the European and Asian cohorts. CONCLUSION/ INTERPRETATION: This study confirms the high burden of large and small-vessel disease complications manifest in American Indian people with younger-onset diabetes.
AIMS/HYPOTHESIS: This study compared the incidence of vascular disease in subjects with younger-onset diabetes from different ethnic groups. METHODS: The incidence of vascular disease endpoints has been studied in a sub-group (n = 994) of participants of the World Health Organization Multinational Study of Vascular Disease in Diabetes (WHO MSVDD) who had younger-onset diabetes (diagnosed before the age of 30 years). The study participants have been divided into European (n = 631), Asian (n = 84) and American Indian (n = 91) cohorts. RESULTS: For Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus, American Indian men had a higher incidence of lower-extremity amputation and renal failure than the other cohorts, whereas European women had a higher incidence of angina than other cohorts. American Indians also had a higher incidence of any retinopathy, clinical proteinuria and albuminuria than the European and Asian cohorts. CONCLUSION/ INTERPRETATION: This study confirms the high burden of large and small-vessel disease complications manifest in American Indian people with younger-onset diabetes.
Authors: Deborah Conte Santos; Laura Gomes Nunes de Melo; Marcela Haas Pizarro; Bianca S V Barros; Carlos Antonio Negrato; Luís Cristóvão Porto; Dayse A Silva; Karla Rezende Guerra Drummond; Luiza Harcar Muniz; Tessa Cerqueria Lemos Mattos; André Araújo Pinheiro; Felipe Mallmann; Franz Schubert Lopes Leal; Fernando Korn Malerbi; Paulo Henrique Morales; Marília Brito Gomes Journal: Acta Diabetol Date: 2020-03-03 Impact factor: 4.280
Authors: Gillian A Whalley; Silmara Gusso; Paul Hofman; Wayne Cutfield; Katrina K Poppe; Robert N Doughty; J Chris Baldi Journal: Diabetes Care Date: 2009-02-05 Impact factor: 17.152