Literature DB >> 11586296

Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males.

H Kurahashi1, B S Emanuel.   

Abstract

Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.

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Mesh：

Year:  2001        PMID： 11586296     DOI： 10.1038/ng1001-139

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  42 in total

Review 1.  Chromosomal translocations and palindromic AT-rich repeats.

Authors:  Takema Kato; Hiroki Kurahashi; Beverly S Emanuel
Journal:  Curr Opin Genet Dev       Date:  2012-03-06       Impact factor: 5.578

2.  A palindrome-mediated mechanism distinguishes translocations involving LCR-B of chromosome 22q11.2.

Authors:  Anthony L Gotter; Tamim H Shaikh; Marcia L Budarf; C Harker Rhodes; Beverly S Emanuel
Journal:  Hum Mol Genet       Date:  2003-11-12       Impact factor: 6.150

3.  A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: the t(8;22)(q24.13;q11.21).

Authors:  Molly B Sheridan; Takema Kato; Chad Haldeman-Englert; G Reza Jalali; Jeff M Milunsky; Ying Zou; Ruediger Klaes; Georgio Gimelli; Stefania Gimelli; Robert M Gemmill; Harry A Drabkin; April M Hacker; Julia Brown; David Tomkins; Tamim H Shaikh; Hiroki Kurahashi; Elaine H Zackai; Beverly S Emanuel
Journal:  Am J Hum Genet       Date:  2010-07-30       Impact factor: 11.025

4.  Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm.

Authors:  Maoqing Tong; Takema Kato; Kouji Yamada; Hidehito Inagaki; Hiroshi Kogo; Tamae Ohye; Makiko Tsutsumi; Jieru Wang; Beverly S Emanuel; Hiroki Kurahashi
Journal:  Hum Mol Genet       Date:  2010-04-13       Impact factor: 6.150

Review 5.  Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences.

Authors:  Ram-Shankar Mani; Arul M Chinnaiyan
Journal:  Nat Rev Genet       Date:  2010-11-03       Impact factor: 53.242

Review 6.  The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements.

Authors:  H Kurahashi; H Inagaki; T Ohye; H Kogo; M Tsutsumi; T Kato; M Tong; B S Emanuel
Journal:  Clin Genet       Date:  2010-10       Impact factor: 4.438

7.  Palindromic AT-rich repeat in the NF1 gene is hypervariable in humans and evolutionarily conserved in primates.

Authors:  Hidehito Inagaki; Tamae Ohye; Hiroshi Kogo; Kouji Yamada; Hiroe Kowa; Tamim H Shaikh; Beverly S Emanuel; Hiroki Kurahashi
Journal:  Hum Mutat       Date:  2005-10       Impact factor: 4.878

8.  Paternal origin of the de novo constitutional t(11;22)(q23;q11).

Authors:  Tamae Ohye; Hidehito Inagaki; Hiroshi Kogo; Makiko Tsutsumi; Takema Kato; Maoqing Tong; Merryn V E Macville; Livija Medne; Elaine H Zackai; Beverly S Emanuel; Hiroki Kurahashi
Journal:  Eur J Hum Genet       Date:  2010-02-24       Impact factor: 4.246

Review 9.  Palindrome-mediated chromosomal translocations in humans.

Authors:  Hiroki Kurahashi; Hidehito Inagaki; Tamae Ohye; Hiroshi Kogo; Takema Kato; Beverly S Emanuel
Journal:  DNA Repair (Amst)       Date:  2006-07-10

10.  Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation.

Authors:  Takema Kato; Colleen P Franconi; Molly B Sheridan; April M Hacker; Hidehito Inagakai; Thomas W Glover; Martin F Arlt; Harry A Drabkin; Robert M Gemmill; Hiroki Kurahashi; Beverly S Emanuel
Journal:  Cancer Genet       Date:  2014-03-18
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