| Literature DB >> 11586295 |
Y Wu1, M J Berends, R H Sijmons, R G Mensink, E Verlind, K A Kooi, T van der Sluis, C Kempinga, A G van dDer Zee, H Hollema, C H Buys, J H Kleibeuker, R M Hofstra.
Abstract
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for mutations in 39 HNPCC families and in 288 patients suspected of having HNPCC. We identified ten different germline MLH3 variants, one frameshift and nine missense mutations, in 12 patients suspected of HNPCC. Three of the 12 also carried a mutation in MSH6.Entities:
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Year: 2001 PMID： 11586295 DOI： 10.1038/ng1001-137
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330