Literature DB >> 11583063

The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.

C R Worz1, M Bottorff.   

Abstract

The objectives of this review are to discuss the role of cytochrome P450 (CYP450) isoforms in drug metabolism, to explain differences in metabolism among the HMG-CoA reductase inhibitors (HMGs, statins), to review drug-drug and drug-food interaction studies dealing with the HMGs, to present case reports dealing with HMG-related myopathy, to discuss major clinical implications of these case reports and to express an opinion of use of HMGs in clinical practice.

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Year:  2001        PMID： 11583063     DOI： 10.1517/14656566.2.7.1119

Source DB:  PubMed          Journal:  Expert Opin Pharmacother        ISSN： 1465-6566            Impact factor:   3.889


  4 in total

Review 1.  Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

Authors:  Russell A Wilke; Debbie W Lin; Dan M Roden; Paul B Watkins; David Flockhart; Issam Zineh; Kathleen M Giacomini; Ronald M Krauss
Journal:  Nat Rev Drug Discov       Date:  2007-11       Impact factor: 84.694

2.  Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.

Authors:  S W Seto; A L S Au; T Y Lam; S S C Chim; S M Y Lee; S Wan; D C S Tjiu; N Shigemura; A P C Yim; S W Chan; S K W Tsui; G P H Leung; Y W Kwan
Journal:  Br J Pharmacol       Date:  2007-06-11       Impact factor: 8.739

3.  Safety assessment of concurrent statin treatment and evaluation of drug interactions in China.

Authors:  Ming-Ming Yan; Shu-Shan Wu; Yin-Qing Ying; Nan Lu; Ming-Kang Zhong
Journal:  SAGE Open Med       Date:  2018-10-11

Review 4.  Pathophysiological mechanisms of statin-associated myopathies: possible role of the ubiquitin-proteasome system.

Authors:  Amirhossein Sahebkar; Arrigo F G Cicero; Paolo Di Giosia; Irene Pomilio; Cosimo Andrea Stamerra; Paolo Giorgini; Claudio Ferri; Stephan von Haehling; Maciej Banach; Tannaz Jamialahmadi
Journal:  J Cachexia Sarcopenia Muscle       Date:  2020-08-02       Impact factor: 12.910
  4 in total

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