Literature DB >> 115830

Influence of neomycin and metronidazole on colonic microflora of volunteers.

Y Arabi, F Dimock, D W Burdon, J Alexander-Williams, M R Keighley.   

Abstract

The influence on colonic microflora of neomycin and metronidazole alone, or in combination, was studied in volunteers taking a normal diet. Bacterial counts on daily faecal samples revealed that metronidazole had no influence on anaerobic faecal bacteria. Neomycin on the other hand, was effective against sensitive aerobes. However, the combination of neomycin and metronidazole profoundly reduced both aerobic and bacteria. Assay of faecal antibiotic concentrations showed that neomycin achieved high intraluminal levels while metronidazole was undetectable or present at low concentrations.

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Year:  1979        PMID： 115830     DOI： 10.1093/jac/5.5.531

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  16 in total

1.  Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease.

Authors:  Wafa N Al-Nassir; Ajay K Sethi; Yuejin Li; Michael J Pultz; Michelle M Riggs; Curtis J Donskey
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191

2.  Prevention and treatment of infection in colorectal surgery.

Authors:  M R Keighley
Journal:  World J Surg       Date:  1982-05       Impact factor: 3.352

Review 3.  The changing epidemiology of Clostridium difficile infections.

Authors:  J Freeman; M P Bauer; S D Baines; J Corver; W N Fawley; B Goorhuis; E J Kuijper; M H Wilcox
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132

4.  Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals.

Authors:  A Krook; B Lindström; J Kjellander; G Järnerot; L Bodin
Journal:  J Clin Pathol       Date:  1981-06       Impact factor: 3.411

5.  Effect of azithromycin on acute inflammatory lesions and colonic bacterial load in a murine model of experimental colitis.

Authors:  Sanja Plesko; Marko Banić; Vanda Plecko; Branimir Anić; Tomislav Brkić; Heinzl Renata; Ivo Rotkvić
Journal:  Dig Dis Sci       Date:  2009-11-19       Impact factor: 3.199

6.  Administration of different Lactobacillus strains in fermented oatmeal soup: in vivo colonization of human intestinal mucosa and effect on the indigenous flora.

Authors:  M L Johansson; G Molin; B Jeppsson; S Nobaek; S Ahrné; S Bengmark
Journal:  Appl Environ Microbiol       Date:  1993-01       Impact factor: 4.792

7.  Liquid chromatographic assay for metronidazole and tinidazole: pharmacokinetic and metabolic studies in human subjects.

Authors:  I Nilsson-Ehle; B Ursing; P Nilsson-Ehle
Journal:  Antimicrob Agents Chemother       Date:  1981-05       Impact factor: 5.191

8.  Effects of antibiotics on bacterial species composition and metabolic activities in chemostats containing defined populations of human gut microorganisms.

Authors:  Dorothy F Newton; Sandra Macfarlane; George T Macfarlane
Journal:  Antimicrob Agents Chemother       Date:  2013-02-12       Impact factor: 5.191

9.  Treatment of hepatic encephalopathy with metronidazole.

Authors:  M H Morgan; A E Read; D C Speller
Journal:  Gut       Date:  1982-01       Impact factor: 23.059

10.  Identification of risk factors for the development of clostridium difficile-associated diarrhea following treatment of polymicrobial surgical infections.

Authors:  Rosemarie Metzger; Brian R Swenson; Hugo Bonatti; Traci L Hedrick; Tjasa Hranjec; Kimberley A Popovsky; Timothy L Pruett; Robert G Sawyer
Journal:  Ann Surg       Date:  2010-04       Impact factor: 12.969
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