Literature DB >> 11582546

Triterpene constituents from the stem bark of Pinus luchuensis and their DNA topoisomerase II inhibitory effect.

S I Wada1, A Iida, R Tanaka.   

Abstract

Nine lanostane and serratane-type triterpenes including two unknown compounds were isolated from the stem bark of Pinus luchuensis. These new compounds were characterized as 3-oxolanost-9(11)-ene-24S,25-diol (1) and 29-acetoxy-3beta-methoxyserrat-14-en-21alpha-ol (2) on the basis of spectroscopic evidence. Some of these triterpenes were tested for the inhibitory effect on DNA topoisomerase II activity. Compound 1 showed a slightly less potent inhibitory activity with an IC(50) value of 186 microM.

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Year:  2001        PMID： 11582546     DOI： 10.1055/s-2001-17360

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  3 in total

1.  Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells.

Authors:  Imtiyaz Murtaza; Mohammad Saleem; Vaqar Mustafa Adhami; Bilal Bin Hafeez; Hasan Mukhtar
Journal:  Cancer Res       Date:  2009-01-27       Impact factor: 12.701

2.  Dietary terpenoids and prostate cancer chemoprevention.

Authors:  Thangaiyan Rabi; Sanjay Gupta
Journal:  Front Biosci       Date:  2008-05-01

3.  Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells.

Authors:  Yao Yuan; Jiewei Wu; Bailin Li; Jia Niu; Haibo Tan; Shengxiang Qiu
Journal:  Sci Rep       Date:  2018-01-17       Impact factor: 4.379
  3 in total

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