Literature DB >> 11582522

CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes.

K Nakagaki1, K Nakagaki1, K Takahashi, D Schols, E De Clercq, T Tabira.   

Abstract

Feline astrocytes were productively infected with the Crandell feline kidney (CrFK) cell-adapted feline immunodeficiency virus (FIV) Petaluma strain in a primary culture. They expressed mRNA of CXCR4, and the FIV infection was blocked by stromal cell-derived factor 1alpha (SDF-1alpha), SDF-1beta, or the bicyclam AMD3100 in a dose-dependent manner. These observations suggest that, like FIV infection in CrFK cells and lymphocytes, the virus uses CXCR4 as a primary receptor for infecting astrocytes and this can be a possible natural model for AIDS dementia complex.

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Year:  2001        PMID： 11582522     DOI： 10.1080/135502801753170354

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  47 in total

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Journal:  N Engl J Med       Date:  1995-04-06       Impact factor: 91.245

4.  Specific tropism of HIV-1 for microglial cells in primary human brain cultures.

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5.  Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.

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Journal:  J Immunol       Date:  1999-08-01       Impact factor: 5.422

6.  Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes.

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Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

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Authors:  C R Mackay
Journal:  J Exp Med       Date:  1996-09-01       Impact factor: 14.307

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Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

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Journal:  J Gen Virol       Date:  1994-05       Impact factor: 3.891

10.  A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes.

Authors:  H S Nottet; M Jett; C R Flanagan; Q H Zhai; Y Persidsky; A Rizzino; E W Bernton; P Genis; T Baldwin; J Schwartz
Journal:  J Immunol       Date:  1995-04-01       Impact factor: 5.422
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  7 in total

Review 1.  FIV and neuroAIDS.

Authors:  Howard S Fox; Tom R Phillips
Journal:  J Neurovirol       Date:  2002-06       Impact factor: 2.643

Review 2.  Lentiviral neuropathogenesis: comparative neuroinvasion, neurotropism, neurovirulence, and host neurosusceptibility.

Authors:  Megan K Patrick; James B Johnston; Christopher Power
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103

3.  Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium.

Authors:  Lena Al-Harti; Jeymohan Joseph; Avindra Nath
Journal:  J Neurovirol       Date:  2018-11-05       Impact factor: 2.643

4.  In vivo CXCR4 expression, lymphoid cell phenotype, and feline immunodeficiency virus infection.

Authors:  Sean P Troth; Alan D Dean; Edward A Hoover
Journal:  Vet Immunol Immunopathol       Date:  2008-01-19       Impact factor: 2.046

5.  Methamphetamine enhances cell-associated feline immunodeficiency virus replication in astrocytes.

Authors:  Mikhail A Gavrilin; Lawrence E Mathes; Michael Podell
Journal:  J Neurovirol       Date:  2002-06       Impact factor: 2.643

Review 6.  Feline immunodeficiency virus neuropathogenesis: from cats to calcium.

Authors:  Rick B Meeker
Journal:  J Neuroimmune Pharmacol       Date:  2006-11-28       Impact factor: 4.147

7.  Ramified feline microglia selects for distinct variants of feline immunodeficiency virus during early central nervous system infection.

Authors:  Andreas Hein; Holger Schuh; Simone Thiel; Jean-Pierre Martin; Rüdiger Dörries
Journal:  J Neurovirol       Date:  2003-08       Impact factor: 2.643
  7 in total

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