Literature DB >> 1158193

The relative potency of the Crick-Harper-Raper unit and the GIH clinical unit of secretin.

J M Braganza, H T Howat, G Kay.   

Abstract

A reinvestigation of the relationship between the Crick-Harper-Raper (CHR) and the GIH clinical units (CU) of secretin has been undertaken in anaesthetized cats with the knowledge that for some time before 1970 the CHR standard used by The Boots Company to assay secretin had lost some specific activity. One clinical unit of GIH secretin (batch no. 17421) is 3-8 times more potent than 1 Crick-Harper-Raper unit of restandardized Boots secretin (batch no. 142) in increasing the flow rate of pancreatic juice, and four times more potent in increasing the amount of bicarbonate.

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Year:  1975        PMID： 1158193      PMCID： PMC1410979          DOI： 10.1136/gut.16.7.549

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  9 in total

1.  The effect of urogastrone, enterogastrone and mepyramine maleate on gastric and pancreatic secretion.

Authors:  H T HOWAT; B SCHOFIELD
Journal:  J Physiol       Date:  1954-01       Impact factor: 5.182

2.  The control of the external secretion of the pancreas in cats.

Authors:  A A Harper; C C Vass
Journal:  J Physiol       Date:  1941-06-30       Impact factor: 5.182

3.  On the preparation of secretin and pancreozymin.

Authors:  J CRICK; A A HARPER; H S RAPER
Journal:  J Physiol       Date:  1949-12       Impact factor: 5.182

4.  Immunological potency and stability of native and synthetic secretins.

Authors:  G Boden; V P Dinoso; O E Owen
Journal:  Gastroenterology       Date:  1974-12       Impact factor: 22.682

5.  [Maximum bicarbonate secretion of the human pancreas].

Authors:  M Vagne; L Descos; P Martin
Journal:  C R Seances Soc Biol Fil       Date:  1969

6.  Relative potency of commercial secretins.

Authors:  G F Stening; M Vagne; M I Grossman
Journal:  Gastroenterology       Date:  1968-12       Impact factor: 22.682

7.  Comparison of pancreatic responses to natural and synthetic secretins in conscious cats.

Authors:  S J Konturek
Journal:  Am J Dig Dis       Date:  1969-08

8.  On the biological assay of secretin. The reference standard.

Authors:  J E Jorpes; V Mutt
Journal:  Acta Physiol Scand       Date:  1966-03

9.  A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin.

Authors:  P BURTON; D G EVANS; A A HARPER; T HOWATH; S OLEESKY; J E SCOTT; H VARLEY
Journal:  Gut       Date:  1960-06       Impact factor: 23.059
  9 in total
  4 in total

1.  Proceedings: The determination of the fatty acid profile of lecithin from human amniotic fluid and the pharyngeal aspirate of the new-born.

Authors:  C M Hill
Journal:  J Physiol       Date:  1976-05       Impact factor: 5.182

Review 2.  Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 1. Secretagogues used in tests of pancreatic secretion.

Authors:  E J Boyd; K G Wormsley
Journal:  Int J Pancreatol       Date:  1987-06

3.  A comparison of the pepsin stimulating effects of secretin preparations.

Authors:  J M Braganza; H T Howat; G H Kay
Journal:  J Physiol       Date:  1976-06       Impact factor: 5.182

4.  Hypersecretion of biliary fatty acids in patients with exocrine pancreatic disease.

Authors:  M Taj; P Rose; L P Hunt; G N Smith; J M Braganza
Journal:  Int J Pancreatol       Date:  1986-12
  4 in total

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