| Literature DB >> 11580982 |
Abstract
Entrapment of antigens in biodegradable particles for mucosal immunisation has given successful outcomes in animals, but not as yet in man. Formulations using genuinely stable biocompatible nanoparticles with co-entrapped mucosal adjuvants and/or with surface-conjugated human M-cell-targeting ligands may lead to better uptake of intact antigen by Peyer's patch M cells and delivery to antigen-presenting cells.Entities:
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Year: 2001 PMID: 11580982 DOI: 10.1016/s1286-4579(01)01445-9
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700