| Literature DB >> 11580886 |
H T Orr1.
Abstract
The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating SCA7-induced retinal degeneration to a disruption of the photoreceptor-specific transcription factor CRX.Entities:
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Year: 2001 PMID： 11580886 DOI： 10.1016/s0896-6273(01)00435-4
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173