Literature DB >> 1158081

Protective effect of Pepto-Bismol liquid on the gastric mucosa of rats.

M M Goldenberg, L J Honkomp, S E Burrous, A W Castellion.   

Abstract

Pepto-Bismol liquid (primary active constituent, bismuth subsalicy-late) protected the gastric mucosa of rats against the formation of hemorrhagic lesions or erosions in response to cold + restraint stress, to a combination of aspirin and cold + restraint stress, and to ethyl alcohol. The protective effect of Pepto-Bismol in these studies was clearly demonstrated. Although the mechanism of action of Pepto-Bismol was not delineated, there was a suggestion that the degree of coating of the gastric mucosa was related to protection.

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Year:  1975        PMID: 1158081

Source DB:  PubMed          Journal:  Gastroenterology        ISSN: 0016-5085            Impact factor:   22.682


  2 in total

1.  Bismuth subsalicylate reduces peptic injury of the oesophagus in rabbits.

Authors:  H P Tay; R C Chaparala; J W Harmon; J Huesken; N Saini; F Z Hakki; E J Schweitzer
Journal:  Gut       Date:  1990-01       Impact factor: 23.059

2.  Gastroprotective effect of ranitidine bismuth citrate is associated with increased mucus bismuth concentration in rats.

Authors:  S Tanaka; P H Guth; G Paulsen; J D Kaunitz
Journal:  Gut       Date:  1996-08       Impact factor: 23.059

  2 in total

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