Genetic regulation of preimplantation embryo survival.

Mammalian embryonic death is the most common outcome of fertilization. This review focuses on the recent advances concerning genetic regulation of preimplantation embryo survival. The predominant role of the Ped(preimplantation embryo development) gene, which regulates fast or slow cleavage of preimplantation mouse embryos, and its implication on embryo survival are discussed. Recent morphological and biochemical observations suggested that programmed cell death was an essential mechanism in preimplantation embryo fragmentation and survival, thus leading to original investigations on apoptosis and apoptosis-related genes. Other genes, transcripts, or proteins seem to be involved in embryo development and control of survival. In particular, the role of heat shock proteins (HSP), telomerase activity (human telomerase catalytic subunit hTCS), and the developmental significance of regulatory protein polarization (leptin, STAT 3) in preimplantation embryos are discussed.