| Literature DB >> 1157964 |
V P Dixit, N K Lohiya, M Agawal.
Abstract
Chronic administration of alpha-chlorohydrin (8 mg/kg for 30 days, caused lesions in the testis of dog. Seminiferous tubules presented marked degenerative changes. Leydig cell hypertrophy was conspicous. Epididymal epithelium was regressed and the lumen was devoid of spermatozoa. Obstruction of the epididymal lumen was not seen. Alpha-Chlorohydrin inhibited the synthesis of RNA and sialic acid in the testis, caput epidiymis, corpus epididymis, and cauda epididymis. The total cholesterol per gram of testis was increased significantly after alpha-chlorohydrin administration. The anti-androgenic nature of alpha-chlorohydrin is suggested.Entities:
Keywords: Alcohols; Alpha-chlorohydrin--side effects; Animals, Laboratory; Biology; Clinical Research; Contraceptive Agents, Male; Epididymis; Genitalia; Genitalia, Male; Ingredients And Chemicals; Organic Chemicals; Physiology; Reproduction; Research Methodology; Sperm Maturation Blocking Agents; Spermatogenesis; Testis; Urogenital System
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Year: 1975 PMID： 1157964 DOI： 10.1016/s0015-0282(16)41292-6
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329