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Literature DB >> 11579426

Mitochondria, oxygen free radicals, and apoptosis.

Abstract

Reactive oxygen species (ROS) generated by mitochondria are produced as by-products of normal oxidative metabolism. The fate of these species is governed by a number of factors that vary from tissue to tissue in mammals and may be involved in the pathogenesis of disease. Reactive oxygen species are also invoked as agents that are important in the processes which become active in cells undergoing apoptosis. Integration of knowledge surrounding these different aspects of ROS generation is difficult and reveals considerable gaps in our understanding. Copyright 2001 Wiley-Liss, Inc.

Entities: Chemical

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Year: 2001 PMID： 11579426 DOI： 10.1002/ajmg.1398

Source DB: PubMed Journal: Am J Med Genet ISSN： 0148-7299

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Cited

76 in total

1. Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells.

Authors: John P M Wood; Neville N Osborne
Journal: Neurochem Res Date: 2003-10 Impact factor: 3.996

2. S. choloroleuca, S. mirzayanii and S. santolinifolia protect PC12 cells from H(2)O (2)-induced apoptosis by blocking the intrinsic pathway.

Authors: Shabnam Zeighamy Alamdary; Fariba Khodagholi; Fatemeh Shaerzadeh; Niloufar Ansari; Ali Sonboli; Solaleh Khoramian Tusi
Journal: Cytotechnology Date: 2011-12-31 Impact factor: 2.058

3. Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria.

Authors: Rebecca Oelkrug; Maria Kutschke; Carola W Meyer; Gerhard Heldmaier; Martin Jastroch
Journal: J Biol Chem Date: 2010-05-13 Impact factor: 5.157

4. Myrtenal attenuates diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades.

Authors: Lingaiah Hari Babu; Srinivasan Perumal; Maruthaiveeran Periyasamy Balasubramanian
Journal: Cell Oncol (Dordr) Date: 2012-06-22 Impact factor: 6.730

5. Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC.

Authors: Richard D Dinnen; Yuehua Mao; Wanglong Qiu; Nicholas Cassai; Vesna N Slavkovich; Gwen Nichols; Gloria H Su; Paul Brandt-Rauf; Robert L Fine
Journal: Mol Cancer Ther Date: 2013-10-14 Impact factor: 6.261

Mitochondria, oxygen free radicals, and apoptosis.

1. Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells.

2. S. choloroleuca, S. mirzayanii and S. santolinifolia protect PC12 cells from H(2)O (2)-induced apoptosis by blocking the intrinsic pathway.

3. Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria.

4. Myrtenal attenuates diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades.

5. Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC.

Review 6. Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology.

7. Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase.

Review 8. The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis.

9. Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages.

10. Essential role for Nix in autophagic maturation of erythroid cells.