Literature DB >> 11579257

A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.

E Z Tchilian1, D L Wallace, R Dawes, N Imami, C Burton, F Gotch, P C Beverley.   

Abstract

The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection.

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Year:  2001        PMID： 11579257     DOI： 10.1097/00002030-200109280-00024

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  19 in total

1.  Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8+ effector-memory T-cell repertoire in vivo.

Authors:  Dirk Meyer-Olson; Brenna C Simons; Joseph A Conrad; Rita M Smith; Louise Barnett; Shelly L Lorey; Coley B Duncan; Ramesh Ramalingam; Spyros A Kalams
Journal:  Blood       Date:  2010-04-27       Impact factor: 22.113

Review 2.  CD45: all is not yet crystal clear.

Authors:  Nick Holmes
Journal:  Immunology       Date:  2006-02       Impact factor: 7.397

3.  Combinatorial control of signal-induced exon repression by hnRNP L and PSF.

Authors:  Alexis A Melton; Jason Jackson; Jiarong Wang; Kristen W Lynch
Journal:  Mol Cell Biol       Date:  2007-07-30       Impact factor: 4.272

4.  Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.

Authors:  R Dawes; B Hennig; W Irving; S Petrova; S Boxall; V Ward; D Wallace; D C Macallan; M Thursz; A Hill; W Bodmer; P C L Beverley; E Z Tchilian
Journal:  J Med Genet       Date:  2006-02-27       Impact factor: 6.318

5.  Geographical distribution and disease associations of the CD45 exon 6 138G variant.

Authors:  Victoria Ward; Branwen J Hennig; Kouzo Hirai; Hideki Tahara; Akihiro Tamori; Ritu Dawes; Mineki Saito; Charles Bangham; Henry Stephens; Anne E Goldfeld; Warunee Kunachiwa; Nipapan Leetrakool; Julian Hopkin; Sarah Dunstan; Adrian Hill; Walter Bodmer; Peter C L Beverley; Elma Z Tchilian
Journal:  Immunogenetics       Date:  2006-03-15       Impact factor: 2.846

Review 6.  CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans.

Authors:  Tara Stanton; Sally Boxall; Andrea Bennett; Pontiano Kaleebu; Christine Watera; Jimmy Whitworth; Neil French; Ritu Dawes; Adrian V S Hill; Walter Bodmer; Peter C L Beverley; Elma Z Tchilian
Journal:  Immunogenetics       Date:  2004-04-01       Impact factor: 2.846

7.  Identification of cells deficient in signaling-induced alternative splicing by use of somatic cell genetics.

Authors:  Paul Sheives; Kristen W Lynch
Journal:  RNA       Date:  2002-12       Impact factor: 4.942

8.  Combinations of CD45 isoforms are crucial for immune function and disease.

Authors:  Ritu Dawes; Svetla Petrova; Zhe Liu; David Wraith; Peter C L Beverley; Elma Z Tchilian
Journal:  J Immunol       Date:  2006-03-15       Impact factor: 5.422

Review 9.  Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn.

Authors:  Nicole M Martinez; Kristen W Lynch
Journal:  Immunol Rev       Date:  2013-05       Impact factor: 12.988

10.  Altered CD45 isoform expression in C77G carriers influences cytokine responsiveness and adhesion properties of T cells.

Authors:  A Windhagen; D Sönmez; H T Hornig-Do; A Kalinowsky; R Schwinzer
Journal:  Clin Exp Immunol       Date:  2007-09-28       Impact factor: 4.330
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