A Szabo1, E Billett, J Turner. 1. Department of Life Sciences, Nottingham Trent University, Nottingham, UK.
Abstract
OBJECTIVES: To determine in this pilot study whether aerobic exercise affects phenylacetic acid concentration in the urine. METHODS: Twenty healthy men provided 24 hour urine samples on two consecutive days for the determination of phenylacetic acid levels. Before and during day 1, subjects refrained from physical activity; on day 2 subjects ran on a treadmill at 70% of their maximal heart rate reserve (MHRR) for 30 minutes. RESULTS: The 24 hour mean urinary concentration of phenylacetic acid was increased by 77% after exercise. CONCLUSION: As phenylacetic acid concentration in urine reflects phenylethylamine level, which is known to have antidepressant effects, phenylethylamine may be linked to the therapeutic effects of physical exercise on depression.
OBJECTIVES: To determine in this pilot study whether aerobic exercise affects phenylacetic acid concentration in the urine. METHODS: Twenty healthy men provided 24 hour urine samples on two consecutive days for the determination of phenylacetic acid levels. Before and during day 1, subjects refrained from physical activity; on day 2 subjects ran on a treadmill at 70% of their maximal heart rate reserve (MHRR) for 30 minutes. RESULTS: The 24 hour mean urinary concentration of phenylacetic acid was increased by 77% after exercise. CONCLUSION: As phenylacetic acid concentration in urine reflects phenylethylamine level, which is known to have antidepressant effects, phenylethylamine may be linked to the therapeutic effects of physical exercise on depression.
Authors: Xuemei Sui; John Ott; Katie Becofsky; Carl J Lavie; Linda Ernstsen; Jiajia Zhang; Steven N Blair Journal: Mayo Clin Proc Date: 2017-05-09 Impact factor: 7.616
Authors: Xiaoqun Zhang; Ioannis Mantas; Alexandra Alvarsson; Takashi Yoshitake; Mohammadreza Shariatgorji; Marcela Pereira; Anna Nilsson; Jan Kehr; Per E Andrén; Mark J Millan; Karima Chergui; Per Svenningsson Journal: Front Pharmacol Date: 2018-03-01 Impact factor: 5.810