Literature DB >> 11578842

Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells.

S Tsutsumi1, A Tomioka, M Sudo, A Nakamura, K Shirakura, K Takagishi, K Kohama.   

Abstract

Propofol (2,6-diisopropylphenol) is an intravenous anesthetic agent structurally unrelated to any other intravenous anesthetics. We examined the effect of propofol on a rat vanilloid receptor that was expressed in the human embryonic kidney (HEK) 293 cells by using calcium imaging method. Propofol caused a concentration-dependent increase in [Ca(2+)](i) in the HEK293 cells with the receptor. These responses were inhibited by removing extracellular calcium ions. The propofol-evoked increase in [Ca(2+)](i) in the HEK293 cells with the receptor was partially inhibited by capsazepine, a competitive antagonist of capsaicin. We conclude that propofol acts as an agonist for the receptor.

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Year:  2001        PMID： 11578842     DOI： 10.1016/s0304-3940(01)02185-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

Review 1.  Manipulation of the endocannabinoid system by a general anaesthetic.

Authors:  Vincenzo Di Marzo
Journal:  Br J Pharmacol       Date:  2003-07       Impact factor: 8.739

2.  Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.

Authors:  Kazuhiro Fukushima; Yoko Aoi; Shinichi Kato; Koji Takeuchi
Journal:  World J Gastroenterol       Date:  2006-05-21       Impact factor: 5.742

3.  The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors.

Authors:  Michael J M Fischer; Andreas Leffler; Florian Niedermirtl; Katrin Kistner; Mirjam Eberhardt; Peter W Reeh; Carla Nau
Journal:  J Biol Chem       Date:  2010-09-07       Impact factor: 5.157

4.  The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat.

Authors:  Kenichi Takechi; Mirela Iodi Carstens; Amanda H Klein; E Carstens
Journal:  Anesth Analg       Date:  2013-01-21       Impact factor: 5.108

5.  Effect of lafutidine, a histamine H2-receptor antagonist, on gastric mucosal blood flow and duodenal HCO3- secretion in rats: relation to capsaicin-sensitive afferent neurons.

Authors:  Hiroshi Mimaki; Shigeru Kagawa; Masako Aoi; Shinichi Kato; Tsutumi Satoshi; Kazuhiro Kohama; Koji Takeuchi
Journal:  Dig Dis Sci       Date:  2002-12       Impact factor: 3.199

6.  Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channels.

Authors:  Sayantani Sinha; Pritam Sinharoy; Ian N Bratz; Derek S Damron
Journal:  PLoS One       Date:  2015-04-01       Impact factor: 3.240

7.  Paradoxic effects of propofol on visceral pain induced by various TRPV1 agonists.

Authors:  Wenjin Ji; Can Cui; Zhiwei Zhang; Jiexian Liang
Journal:  Exp Ther Med       Date:  2013-02-05       Impact factor: 2.447

8.  Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects.

Authors:  E P Wilder-Smith; W-Y Ong; Y Guo; A W-L Chow
Journal:  Histopathology       Date:  2007-11       Impact factor: 5.087
  8 in total

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