Literature DB >> 11577376

Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis.

P G Scotton1, F Pea, M Giobbia, M Baraldo, A Vaglia, M Furlanut.   

Abstract

We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (C(L)/C(P)) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis. CSF levofloxacin concentration at 2 hours after dosing was 1.99+/-0.67 microg/mL, and the C(L)/C(P) at 2 hours after dosing was 0.34+/-0.09.

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Year:  2001        PMID： 11577376     DOI： 10.1086/323406

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  10 in total

Review 1.  Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections.

Authors:  Roland Nau; Fritz Sörgel; Helmut Eiffert
Journal:  Clin Microbiol Rev       Date:  2010-10       Impact factor: 26.132

2.  Meropenem prevents levofloxacin-induced resistance in penicillin-resistant pneumococci and acts synergistically with levofloxacin in experimental meningitis.

Authors:  P Cottagnoud; M Cottagnoud; F Acosta; L Flatz; F Kühn; A Stucki; J Entenza
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2003-10-14       Impact factor: 3.267

Review 3.  Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

Authors:  Amanda K Sullins; Susan M Abdel-Rahman
Journal:  Paediatr Drugs       Date:  2013-04       Impact factor: 3.022

4.  Levofloxacin disposition in cerebrospinal fluid in patients with external ventriculostomy.

Authors:  Federico Pea; Federica Pavan; Ennio Nascimben; Claudio Benetton; Pier Giorgio Scotton; Alberto Vaglia; Mario Furlanut
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

5.  Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro.

Authors:  F Kühn; M Cottagnoud; F Acosta; L Flatz; J Entenza; P Cottagnoud
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

Review 6.  Management of meningitis due to antibiotic-resistant Acinetobacter species.

Authors:  Baek-Nam Kim; Anton Y Peleg; Thomas P Lodise; Jeffrey Lipman; Jian Li; Roger Nation; David L Paterson
Journal:  Lancet Infect Dis       Date:  2009-04       Impact factor: 25.071

7.  Pharmacokinetics and pharmacodynamics of intravenous levofloxacin in patients with early-onset ventilator-associated pneumonia.

Authors:  Federico Pea; Elena Di Qual; Aldo Cusenza; Loris Brollo; Marco Baldassarre; Mario Furlanut
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

Review 8.  Meningitis in a Chinese adult patient caused by Mycoplasma hominis: a rare infection and literature review.

Authors:  Menglan Zhou; Peng Wang; Sharon Chen; Bin Du; Jinlong Du; Fengdan Wang; Meng Xiao; Fanrong Kong; Yingchun Xu
Journal:  BMC Infect Dis       Date:  2016-10-12       Impact factor: 3.090

9.  Sequential Intravenous-Oral Therapy for Pediatric Streptococcus anginosus Intracranial Infections.

Authors:  Daniel S Dodson; Heather R Heizer; James T Gaensbauer
Journal:  Open Forum Infect Dis       Date:  2022-01-06       Impact factor: 3.835

10.  Systemic fluoroquinolone prescriptions for hospitalized children in Belgium, results of a multicenter retrospective drug utilization study.

Authors:  Kevin Meesters; Reiner Mauel; Evelyn Dhont; Johan Vande Walle; Pauline De Bruyne
Journal:  BMC Infect Dis       Date:  2018-02-23       Impact factor: 3.090
  10 in total

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