| Literature DB >> 11574927 |
F Dieli1, M Troye-Blomberg, J Ivanyi, J J Fournié, A M Krensky, M Bonneville, M A Peyrat, N Caccamo, G Sireci, A Salerno.
Abstract
Contribution of Vgamma9/Vdelta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vgamma9/Vdelta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vgamma9/Vdelta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.Entities:
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Year: 2001 PMID： 11574927 DOI： 10.1086/323600
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226