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Literature DB >> 11574278

HLA-G: a shield against inflammatory aggression.

E D Carosella¹, P Moreau, S Aractingi, N Rouas-Freiss.

Abstract

Recent developments in the field of HLA-G research have revealed that, besides its involvement during pregnancy, HLA-G is expressed in peripheral tissues during pathological processes, such as viral infections, malignancies and organ transplantation. Here, we discuss recent findings regarding the influence of HLA-G on the T helper (Th) cytokine balance (favoring Th2-type responses), and the expression of HLA-G during chronic, cutaneous inflammatory diseases, such as psoriasis and atopic dermatitis. We propose a novel role for HLA-G as a tissue-protective molecule in inflammatory responses.

Entities: Disease Gene

Mesh：

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Year: 2001 PMID： 11574278 DOI： 10.1016/s1471-4906(01)02007-5

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

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Cited

42 in total

Review 1. Interplay between T helper type 1 and type 2 cytokines and soluble major histocompatibility complex molecules: a paradigm in pregnancy.

Authors: Irene Athanassakis; S Vassiliadis
Journal: Immunology Date: 2002-11 Impact factor: 7.397

Review 2. Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.

Authors: T Kevin Howcroft; Dinah S Singer
Journal: Immunol Res Date: 2003 Impact factor: 2.829

Review 3. Immunology of pregnancy. Implications for the mother.

Authors: Jill A Poole; Henry N Claman
Journal: Clin Rev Allergy Immunol Date: 2004-06 Impact factor: 8.667

Review 4. Emerging topics and new perspectives on HLA-G.

Authors: Enrico Fainardi; Massimiliano Castellazzi; Marina Stignani; Fabio Morandi; Gwenaëlle Sana; Rafael Gonzalez; Vito Pistoia; Olavio Roberto Baricordi; Etienne Sokal; Josè Peña
Journal: Cell Mol Life Sci Date: 2010-11-16 Impact factor: 9.261

5. Elevated levels of soluble non-classical major histocompatibility class I molecule human leucocyte antigen (HLA)-G in the blood of HIV-infected patients with or without visceral leishmaniasis.

Authors: L Donaghy; F Gros; L Amiot; C Mary; A Maillard; C Guiguen; J-P Gangneux
Journal: Clin Exp Immunol Date: 2007-02 Impact factor: 4.330

Review 6. New aspects in celiac disease.

Authors: M I Torres; M A López Casado; A Ríos
Journal: World J Gastroenterol Date: 2007-02-28 Impact factor: 5.742

HLA-G: a shield against inflammatory aggression.

Review 1. Interplay between T helper type 1 and type 2 cytokines and soluble major histocompatibility complex molecules: a paradigm in pregnancy.

Review 2. Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.

Review 3. Immunology of pregnancy. Implications for the mother.

Review 4. Emerging topics and new perspectives on HLA-G.

5. Elevated levels of soluble non-classical major histocompatibility class I molecule human leucocyte antigen (HLA)-G in the blood of HIV-infected patients with or without visceral leishmaniasis.

Review 6. New aspects in celiac disease.

7. sHLA-G involved in the apoptosis of decidual natural killer cells following Toxoplasma gondii infection.

8. Modulation of HLA-G expression in human neural cells after neurotropic viral infections.

Review 9. Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates.

10. HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract.