Literature DB >> 11574005

Difluorinated Danishefsky's diene: a versatile C(4) building block for the fluorinated six-membered rings.

H Amii1, T Kobayashi, H Terasawa, K Uneyama.   

Abstract

[reaction: see text] A Mg(0)/Me(3)SiCl system was found to be effective for the preparation of difluoro Danishefsky's dienes 2, which involves selective C-F bond cleavage of trifluoromethyl ketones 3. Subsequent hetero Diels-Alder reactions of 2 with aldehydes and imines gave a variety of fluorinated six-membered heterocycles.

Entities:  

Year:  2001        PMID： 11574005     DOI： 10.1021/ol0163631

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Synthesis of α-halo-α,α-difluoromethyl ketones by a trifluoroacetate release/halogenation protocol.

Authors:  Jinu P John; David A Colby
Journal:  J Org Chem       Date:  2011-10-13       Impact factor: 4.354

2.  Carbodefluorination of fluoroalkyl ketones via a carbene-initiated rearrangement strategy.

Authors:  Linxuan Li; Xinyu Zhang; Yongquan Ning; Xiaolong Zhang; Binbin Liu; Zhansong Zhang; Paramasivam Sivaguru; Giuseppe Zanoni; Shuang Li; Edward A Anderson; Xihe Bi
Journal:  Nat Commun       Date:  2022-07-25       Impact factor: 17.694
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.