OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social support in post-MI patients. A total of 2481 patients were recruited (26% with low social support, 39% with depression, and 34% with low social support and depression). Our objective is to describe the rationale, design, and delivery of the ENRICHD intervention. METHODS: Key features of the intervention include the integration of cognitive-behavioral and social learning approaches to the treatment of depression and a diverse set of problems that can contribute to low social support; rapid initiation of treatment after MI; a combination of individual and group modalities; adjunctive pharmacotherapy for severe or intractable depression; training, certification, and supervision of therapists; and quality assurance procedures. RESULTS: The trial's psychosocial and medical outcomes will be presented in future reports. CONCLUSIONS: The ENRICHD protocol targets two complex psychosocial risk factors with a multifaceted intervention, which is delivered in an individualized manner to accommodate a demographically, medically, and psychiatrically diverse patient population. Additional research will be needed to identify optimal matches between patient characteristics and specific components of the intervention.
RCT Entities:
OBJECTIVE:Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social support in post-MI patients. A total of 2481 patients were recruited (26% with low social support, 39% with depression, and 34% with low social support and depression). Our objective is to describe the rationale, design, and delivery of the ENRICHD intervention. METHODS: Key features of the intervention include the integration of cognitive-behavioral and social learning approaches to the treatment of depression and a diverse set of problems that can contribute to low social support; rapid initiation of treatment after MI; a combination of individual and group modalities; adjunctive pharmacotherapy for severe or intractable depression; training, certification, and supervision of therapists; and quality assurance procedures. RESULTS: The trial's psychosocial and medical outcomes will be presented in future reports. CONCLUSIONS: The ENRICHD protocol targets two complex psychosocial risk factors with a multifaceted intervention, which is delivered in an individualized manner to accommodate a demographically, medically, and psychiatrically diverse patient population. Additional research will be needed to identify optimal matches between patient characteristics and specific components of the intervention.
Authors: Kenneth E Freedland; Robert M Carney; Junichiro Hayano; Brian C Steinmeyer; Rebecca L Reese; Annelieke M Roest Journal: J Psychosom Res Date: 2012-01-28 Impact factor: 3.006
Authors: Claire J Han; Biljana Gigic; Martin Schneider; Yakup Kulu; Anita R Peoples; Jennifer Ose; Torsten Kölsch; Paul B Jacobsen; Graham A Colditz; Jane C Figueiredo; William M Grady; Christopher I Li; David Shibata; Erin M Siegel; Adetunji T Toriola; Alexis B Ulrich; Karen L Syrjala; Cornelia M Ulrich Journal: J Cancer Surviv Date: 2020-03-12 Impact factor: 4.442
Authors: Ranak B Trivedi; James A Blumenthal; Christopher O'Connor; Kirkwood Adams; Alan Hinderliter; Carla Dupree; Kristy Johnson; Andrew Sherwood Journal: J Psychosom Res Date: 2009-10 Impact factor: 3.006
Authors: Emily C Gathright; Andrew M Busch; Maria L Buckley; Loren Stabile; Julianne DeAngelis; Matthew C Whited; Wen-Chih Wu Journal: J Cardiopulm Rehabil Prev Date: 2019-01 Impact factor: 2.081
Authors: Annelieke M Roest; Robert M Carney; Kenneth E Freedland; Elisabeth J Martens; Johan Denollet; Peter de Jonge Journal: J Affect Disord Date: 2013-03-11 Impact factor: 4.839
Authors: Amanda S Mixon; Amy P Myers; Cardella L Leak; J Mary Lou Jacobsen; Courtney Cawthon; Kathryn M Goggins; Samuel Nwosu; Jonathan S Schildcrout; John F Schnelle; Theodore Speroff; Sunil Kripalani Journal: Mayo Clin Proc Date: 2014-07-03 Impact factor: 7.616