| Literature DB >> 11572994 |
L A McInnes1, S K Service, V I Reus, G Barnes, O Charlat, S Jawahar, S Lewitzky, Q Yang, Q Duong, M Spesny, C Araya, X Araya, A Gallegos, L Meza, J Molina, R Ramirez, R Mendez, S Silva, E Fournier, S L Batki, C A Mathews, T Neylan, C E Glatt, M A Escamilla, D Luo, P Gajiwala, T Song, S Crook, J B Nguyen, E Roche, J M Meyer, P Leon, L A Sandkuijl, N B Freimer, H Chen.
Abstract
We have searched for genes predisposing to bipolar disorder (BP) by studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated population of the Central Valley of Costa Rica (CVCR). The results of a previous linkage analysis on two extended CVCR BP-I pedigrees, CR001 and CR004, and of linkage disequilibrium (LD) analyses of a CVCR population sample of BP-I patients implicated a candidate region on 18p11.3. We further investigated this region by creating a physical map and developing 4 new microsatellite and 26 single-nucleotide polymorphism markers for typing in the pedigree and population samples. We report the results of fine-scale association analyses in the population sample, as well as evaluation of haplotypes in pedigree CR001. Our results suggest a candidate region containing six genes but also highlight the complexities of LD mapping of common disorders.Entities:
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Year: 2001 PMID： 11572994 PMCID： PMC58756 DOI： 10.1073/pnas.191519098
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205