Literature DB >> 11572924

ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction.

B Liss1, J Roeper.   

Abstract

ATP-sensitive potassium (K(ATP)) channels directly couple the metabolic state of a cell to its electrical activity. Dopaminergic midbrain neurons express alternative types of K(ATP) channels mediating their differential response to mitochondrial complex I inhibition. Because reduced complex I activity is present in Parkinson's Disease, differential K(ATP) channel expression suggests a novel candidate mechanism for selective dopaminergic degeneration.

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Year:  2001        PMID： 11572924     DOI： 10.1152/physiologyonline.2001.16.5.214

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  13 in total

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10.  Role of the ventral striatum in developing anorexia nervosa.

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