| Literature DB >> 1157188 |
P D Braddock, T A Connors, M Jones, A R Khokhar, D H Melzack, M L Tobe.
Abstract
A number of complexes of platinum(II) and platinum(IV) have been prepared, characterised and tested for their ability to cause regression of a mouse plasma cell tumour. All active compounds possess two cis amine ligands but the oxidation state of the platinum is not critical. Relatively minor structural and substituent changes in the amine can lead to major and dramatic changes in the therapeutic index, generally, but not necessarily, associated with changes in toxicity. Some preliminary results on the relationship between structure and solubility are also reported.Entities:
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Year: 1975 PMID： 1157188 DOI： 10.1016/0009-2797(75)90095-2
Source DB: PubMed Journal: Chem Biol Interact ISSN： 0009-2797 Impact factor: 5.192