Literature DB >> 11571755

Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants.

I Mayordomo1, P Sanz.   

Abstract

Human pancreatic glucokinase (GlkB, hexokinase IV) has been expressed in Saccharomyces cerevisiae. The recombinant protein showed similar enzyme kinetics to those described for the original enzyme. When expressed in hxk2 yeast mutants, GlkB complemented both the glucose induction and the glucose repression defects present in the mutant. It was also functional in regulating the activity of the Snf1 kinase complex in response to glucose, participating in the regulation of the Reg1/Glc7 phosphatase complex, as its yeast counterpart. Copyright 2001 John Wiley & Sons, Ltd.

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Year:  2001        PMID： 11571755     DOI： 10.1002/yea.780

Source DB:  PubMed          Journal:  Yeast        ISSN： 0749-503X            Impact factor:   3.239


  7 in total

Review 1.  Sugar sensing and signaling in plants.

Authors:  Filip Rolland; Brandon Moore; Jen Sheen
Journal:  Plant Cell       Date:  2002       Impact factor: 11.277

2.  Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene.

Authors:  Lidia Tomás-Cobos; Pascual Sanz
Journal:  Biochem J       Date:  2002-12-01       Impact factor: 3.857

3.  Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations.

Authors:  Leda Pedelini; Maria Adelaida Garcia-Gimeno; Alberto Marina; Juan M Gomez-Zumaquero; Pablo Rodriguez-Bada; Soledad López-Enriquez; Federico C Soriguer; Antonio L Cuesta-Muñoz; Pascual Sanz
Journal:  Protein Sci       Date:  2005-06-29       Impact factor: 6.725

Review 4.  Glucose signaling in Saccharomyces cerevisiae.

Authors:  George M Santangelo
Journal:  Microbiol Mol Biol Rev       Date:  2006-03       Impact factor: 11.056

5.  Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana.

Authors:  Yunhai Li; Caroline Smith; Fiona Corke; Leiying Zheng; Zara Merali; Peter Ryden; Paul Derbyshire; Keith Waldron; Michael W Bevan
Journal:  Plant Cell       Date:  2007-08-10       Impact factor: 11.277

6.  Tpk3 and Snf1 protein kinases regulate Rgt1 association with Saccharomyces cerevisiae HXK2 promoter.

Authors:  A Palomino; P Herrero; F Moreno
Journal:  Nucleic Acids Res       Date:  2006-03-09       Impact factor: 16.971

7.  The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists.

Authors:  Sven Heinicke; Michael S Livstone; Charles Lu; Rose Oughtred; Fan Kang; Samuel V Angiuoli; Owen White; David Botstein; Kara Dolinski
Journal:  PLoS One       Date:  2007-08-22       Impact factor: 3.240
  7 in total

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