| Literature DB >> 11569620 |
S Isayama1, Y Sugimoto, M Nishiga, C Kamei.
Abstract
We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.Entities:
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Year: 2001 PMID： 11569620 DOI： 10.1254/jjp.86.451
Source DB: PubMed Journal: Jpn J Pharmacol ISSN： 0021-5198