| Literature DB >> 11568896 |
M Paulsen1, A C Ferguson-Smith.
Abstract
Changes in DNA methylation profiles are common features of development and in a number of human diseases, such as cancer and imprinting disorders like Beckwith-Wiedemann and Prader-Willi/Angelman syndromes. This suggests that DNA methylation is required for proper gene regulation during development and in differentiated tissues and has clinical relevance. DNA methylation is also involved in X-chromosome inactivation and the allele-specific silencing of imprinted genes. This review describes possible mechanisms by which DNA methylation can regulate gene expression, using imprinted genes as examples. The molecular basis of methylation-mediated gene regulation is related to changes in chromatin structure and appears to be similar for both imprinted and biallelically expressed genes. Copyright 2001 John Wiley & Sons, Ltd.Entities:
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Year: 2001 PMID： 11568896 DOI： 10.1002/path.890
Source DB: PubMed Journal: J Pathol ISSN： 0022-3417 Impact factor: 7.996