| Literature DB >> 11567663 |
T K Nordt1, J Lohrmann, C Bode.
Abstract
Increased expression of plasminogen activator inhibitor type 1 (PAI-1) is now considered as an independent risk factor for cardiovascular disease. Numerous biochemical factors have been found to regulate the expression of PAI-1 gene and the synthesis of PAI-1 protein. In the recent past, polymorphisms in the PAI-1 gene have been identified and their impact on PAI-1 expression has been characterized. This article will review the current knowledge of these PAI-1 gene polymorphisms (in cell culture epidemiological, and clinical studies) and their role in the development of cardiovascular disease.Entities:
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Year: 2001 PMID： 11567663 DOI： 10.1016/s0049-3848(01)00292-4
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944