Literature DB >> 11567652

Effects of 5-HT(2) receptor antagonists on the anti-immobility effects of imipramine in the forced swimming test with mice.

J Yamada1, Y Sugimoto.   

Abstract

The effects of 5-HT(2) receptor antagonists on antidepressant effects of imipramine were investigated in the forced swimming test. Imipramine induced anti-immobility effects in mice dose dependently. Pretreatment with the 5-HT(2A/2B/2C) receptor antagonist, 4-isopropyl-7-methyl-9-(2-hydroxy-1-methyl-propoxycarbonyl)-4,6A,7,8,9,10,10A-octahydro-indolo[4,3-FG]quinolone maleate (LY 53857) significantly enhanced the anti-immobility effects of imipramine. The 5-HT(2C/2B) receptor antagonist, N-3-pyridinyl-3,5-dihydro-5-methyl-benzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide (SB 206553), also enhanced, while the 5-HT(2A) receptor antagonist, ketanserin, was without effect. These results suggest that blockade of the 5-HT(2C/2B) receptor leads to potentiation of the antidepressant effects of imipramine.

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Year:  2001        PMID： 11567652     DOI： 10.1016/s0014-2999(01)01240-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

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Journal:  Psychopharmacology (Berl)       Date:  2003-04-30       Impact factor: 4.530

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Authors:  Kimberly R Tyeryar; Ashiwel S Undie
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5.  Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus.

Authors:  Y Kroeze; D Peeters; F Boulle; J L Pawluski; D L A van den Hove; H van Bokhoven; H Zhou; J R Homberg
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  5 in total

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