| Literature DB >> 11567141 |
E J Peterson1, M L Woods, S A Dmowski, G Derimanov, M S Jordan, J N Wu, P S Myung, Q H Liu, J T Pribila, B D Freedman, Y Shimizu, G A Koretzky.
Abstract
SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.Entities:
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Year: 2001 PMID： 11567141 DOI： 10.1126/science.1063486
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728