Literature DB >> 11566479

SEE: a tool for the visualization and analysis of rodent exploratory behavior.

D Drai1, I Golani.   

Abstract

The complexity of exploratory behavior creates a need for a visualization and analysis tool that will highlight regularities and help generating new hypotheses about the structure of this behavior. The hypotheses can then be formulated as algorithms that capture the patterns and quantify them. SEE is a Mathematica based software developed by us for the exploration of exploratory behavior. The raw data for SEE are a time series of the animal 's coordinates in space sampled at a rate that allows a meaningful computation of speeds. SEE permits: (i) a visualization of the path of the animal and a computation of the dynamics of activity; (ii) a decomposition of the path into several modes of motion (1st gear, 2nd gear, etc.) and a computation of the typical maximal speeds, the spatial spread, and the proportion of each of these modes; and(iii) a visualization of the location in the environment of stopping episodes, along with their dwell time. These visualizations highlight the presence of preferred places, including the animal's so-called home base, and permits a computation of the spatio-temporal diversity in the location of stopping episodes. The software also: (i) decomposes the animal's path into round trips from the home base, called 'excursions', and computes the number of stops per excursion; (ii) generates a visualization of the phase space (path+speed, traced in a three-dimensional graph) of any progression segment or list of such segments; and (iii) produces a visualization of the way places in the animal's operational world are connected to each other. SEE also permits the definition and computation of behavioral endpoints across any section of any database of raw data. The range of applicability of SEE to various experimental set ups, tracking procedures, species, and preparations is addressed in the discussion.

Mesh:

Year:  2001        PMID: 11566479     DOI: 10.1016/s0149-7634(01)00022-7

Source DB:  PubMed          Journal:  Neurosci Biobehav Rev        ISSN: 0149-7634            Impact factor:   8.989


  50 in total

1.  Fimbria-fornix lesions disrupt the dead reckoning (homing) component of exploratory behavior in mice.

Authors:  Joanna H Gorny; Bogdan Gorny; Douglas G Wallace; Ian Q Whishaw
Journal:  Learn Mem       Date:  2002 Nov-Dec       Impact factor: 2.460

2.  Hebbian analysis of the transformation of medial entorhinal grid-cell inputs to hippocampal place fields.

Authors:  Francesco Savelli; James J Knierim
Journal:  J Neurophysiol       Date:  2010-03-31       Impact factor: 2.714

3.  Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD).

Authors:  Mark C Tucci; Anna Dvorkin-Gheva; Renee Sharma; Leena Taji; Paul Cheon; John Peel; Ashley Kirk; Henry Szechtman
Journal:  Psychopharmacology (Berl)       Date:  2014-02-28       Impact factor: 4.530

4.  Genotype-environment interactions in mouse behavior: a way out of the problem.

Authors:  Neri Kafkafi; Yoav Benjamini; Anat Sakov; Greg I Elmer; Ilan Golani
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-11       Impact factor: 11.205

Review 5.  Dynamic phenotypes: time series analysis techniques for characterizing neuronal and behavioral dynamics.

Authors:  Hemant Bokil; Ofer Tchernichovsky; Partha P Mitra
Journal:  Neuroinformatics       Date:  2006

6.  Differential effects of clorgyline on sensitization to quinpirole in rats tested in small and large environments.

Authors:  Anna Dvorkin; Kirsten E Culver; Henry Szechtman
Journal:  Psychopharmacology (Berl)       Date:  2006-05-11       Impact factor: 4.530

7.  Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia.

Authors:  Thomas S Hnasko; Francisco A Perez; Alex D Scouras; Elizabeth A Stoll; Samuel D Gale; Serge Luquet; Paul E M Phillips; Eric J Kremer; Richard D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-24       Impact factor: 11.205

Review 8.  Quantification of developmental birdsong learning from the subsyllabic scale to cultural evolution.

Authors:  Dina Lipkind; Ofer Tchernichovski
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-21       Impact factor: 11.205

9.  Quantification of behavior.

Authors:  Alan Leshner; Donald W Pfaff
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-13       Impact factor: 11.205

10.  Knots: attractive places with high path tortuosity in mouse open field exploration.

Authors:  Anna Dvorkin; Henry Szechtman; Ilan Golani
Journal:  PLoS Comput Biol       Date:  2010-01-15       Impact factor: 4.475

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