Literature DB >> 1156523

Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.

P R Twentyman, N M Bleehen.   

Abstract

Dose-response curves have been obtained for the response of EMT6 mouse tumour cells in vitro to adriamycin, actinomycin D, nitrogen mustard, BCNU and CCNU. The experiments have been carried out with exponentially growing cells and with cells in early and late plateau phase. The results are discussed with particular reference to discrepancies with the results obtained by other workers in similar systems.

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Year:  1975        PMID： 1156523      PMCID： PMC2009450          DOI： 10.1038/bjc.1975.80

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  16 in total

1.  Differential lethal effect of cytotoxic agents on proliferating and nonproliferating lymphoid cells.

Authors:  H Lin
Journal:  Cancer Res       Date:  1973-07       Impact factor: 12.701

2.  Responses of cycling and noncycling cells to 1,3-bis(2-chloroethyl)-1-nitrosourea and to bleomycin.

Authors:  G M Hahn; L F Gordon; S D Kurkjian
Journal:  Cancer Res       Date:  1974-09       Impact factor: 12.701

3.  Action of actinomycin D, bleomycin and x rays on HeLa cells.

Authors:  Z M Bienkowska; K B Dawson; J H Peacock
Journal:  Br J Radiol       Date:  1973-08       Impact factor: 3.039

4.  Cell survival and repair of plateau-phase cultures after chemotherapy--relevance to tumor therapy and to the in vitro screening of new agents.

Authors:  G R Ray; G M Hahn; M A Bagshaw; S Kurkjian
Journal:  Cancer Chemother Rep       Date:  1973 Nov-Dec

5.  Response of mammalian cells following treatment with bleomycin and 1,3-bis(2-chloroethyl)-1-nitrosourea during plateau phase.

Authors:  S C Barranco; J K Novak; R M Humphrey
Journal:  Cancer Res       Date:  1973-04       Impact factor: 12.701

6.  Cell-cycle specificity and therapeutic effectiveness of cytostatic agents.

Authors:  L M Van Putten; P Lelieveld; L K Kram-Idsenga
Journal:  Cancer Chemother Rep       Date:  1972-12

7.  Survival responses of dividing and nondividing mammalian cells after treatment with hydroxyurea, arabinosylcytosine, or adriamycin.

Authors:  S C Barranco; J K Novak
Journal:  Cancer Res       Date:  1974-07       Impact factor: 12.701

8.  Tumor chemotherapy: efficacy dependent on mode of growth.

Authors:  R F Hagemann; L L Schenken; S Lesher
Journal:  J Natl Cancer Inst       Date:  1973-02       Impact factor: 13.506

9.  Sensitivity of confluent and cycling embryonic hamster cells to sulfur mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and actinomycin D.

Authors:  C J Thatcher; I G Walker
Journal:  J Natl Cancer Inst       Date:  1969-03       Impact factor: 13.506

10.  The sensitivity of cells in exponential and stationary phases of growth to bleomycin and to 1,3-bis(2-chloroethyl)-1-nitrosourea.

Authors:  P R Twentyman; N M Bleehen
Journal:  Br J Cancer       Date:  1973-12       Impact factor: 7.640
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  12 in total

1.  Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors.

Authors:  Sara Rockwell; Yanfeng Liu; Helen A Seow; Kimiko Ishiguro; Raymond P Baumann; Philip G Penketh; Krishnamurthy Shyam; Oluwatoyin M Akintujoye; Peter M Glazer; Alan C Sartorelli
Journal:  Int J Radiat Biol       Date:  2011-12-20       Impact factor: 2.694

2.  Clinical pharmacokinetics of oral CCNU (lomustine).

Authors:  F Y Lee; P Workman; J T Roberts; N M Bleehen
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

3.  Survival and cell cycle kinetics responses of Chinese hamster ovary cells, and clones of human adenocarcinoma of the stomach and astrocytoma to diaziquone (AZQ) in vitro.

Authors:  S C Barranco; G A Schechter; W R Boerwinkle; K A Howell; N H Rubin
Journal:  Invest New Drugs       Date:  1983       Impact factor: 3.850

4.  Effect of various substitutions in positions 1, 2, 3, and 4 of 4-demethoxydaunorubicin and 4-demethoxyadriamycin.

Authors:  A Di Marco; A M Casazza; C Soranzo; G Pratesi
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

Review 5.  Kinetic resistance to anticancer agents.

Authors:  M T Dimanche-Boitrel; C Garrido; B Chauffert
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

6.  Effect of cell density on intracellular adriamycin concentration and cytotoxicity in exponential and plateau phase EMT6 cells.

Authors:  S H Chambers; N M Bleehen; J V Watson
Journal:  Br J Cancer       Date:  1984-03       Impact factor: 7.640

7.  The response to cytotoxic drugs of EMT6 cells treated either as intact or disaggregated spheroids.

Authors:  T T Kwok; P R Twentyman
Journal:  Br J Cancer       Date:  1985-02       Impact factor: 7.640

8.  Evidence for induction and repair of potentially lethal damage in plateau-phase V79 cells after exposure to adriamycin. The importance of removal of adriamycin released from the cells during the post-treatment incubation period.

Authors:  G Iliakis
Journal:  Br J Cancer       Date:  1987-04       Impact factor: 7.640

9.  The clinical value of immunohistochemically demonstrable CEA in breast cancer: a possible method of selecting patients for adjuvant chemotherapy.

Authors:  S R Smith; A Howell; A Minawa; J M Morrison
Journal:  Br J Cancer       Date:  1982-11       Impact factor: 7.640

10.  Cytokinetic factors in drug resistance of Lewis lung carcinoma: comparison of cells freshly isolated from tumours with cells from exponential and plateau-phase cultures.

Authors:  G J Finlay; W R Wilson; B C Baguley
Journal:  Br J Cancer       Date:  1987-12       Impact factor: 7.640
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