Polyamines in the human gut.

Intracellular polyamine concentrations are maintained by endogenous synthesis and uptake of exogenous polyamines from the gastrointestinal lumen. Recently, much attention has been focused on the role of polyamines in tumour pathogenesis and the possible therapeutic value of reducing polyamine concentrations in tumour tissue. Unfortunately, polyamines also appear to be essential for the maintenance of normal gastrointestinal structure and function. The immediate analytical challenge is to make progress in laboratory methods for polyamine class analyses and assessment of polyamine metabolism. An obvious gastroenterological target is to make up for past neglect of the function of these important dietary components.