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Literature DB >> 11564641

A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse.

Abstract

Despite the potential importance of the mouse in studying the pharmacology of aqueous dynamics, measurement of intraocular pressure (IOP) in its very small eye has been problematic. Utilizing a novel servo-null electrophysiologic approach recently applied to the mouse, we have identified a diversity of adenosine-receptor mechanisms in modulating IOP in this species. We report the first evidence that A(3) receptors increase IOP in any species, and verify in the mouse reports with larger mammals that A(1) receptors lower and A(2A) receptors increase IOP.

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Year: 2001 PMID： 11564641 PMCID： PMC1572961 DOI： 10.1038/sj.bjp.0704267

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

17 in total

1. Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.

Authors: A H Li; S Moro; N Forsyth; N Melman; X D Ji; K A Jacobson
Journal: J Med Chem Date: 1999-02-25 Impact factor: 7.446

2. Reliable measurement of mouse intraocular pressure by a servo-null micropipette system.

Authors: M Y Avila; D A Carré; R A Stone; M M Civan
Journal: Invest Ophthalmol Vis Sci Date: 2001-07 Impact factor: 4.799

3. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.

Authors: E Ongini; S Dionisotti; S Gessi; E Irenius; B B Fredholm
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1999-01 Impact factor: 3.000

4. PD 116,948, a highly selective A1 adenosine receptor antagonist.

Authors: S J Haleen; R P Steffen; H W Hamilton
Journal: Life Sci Date: 1987-02-09 Impact factor: 5.037

5. Ocular penetration of pilocarpine in primates.

Authors: C F Asseff; R L Weisman; S M Podos; B Becker
Journal: Am J Ophthalmol Date: 1973-02 Impact factor: 5.258

6. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

Authors: K N Klotz; J Hessling; J Hegler; C Owman; B Kull; B B Fredholm; M J Lohse
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1998-01 Impact factor: 3.000

7. Similarity of A(3)-adenosine and swelling-activated Cl(-) channels in nonpigmented ciliary epithelial cells.

Authors: D A Carré; C H Mitchell; K Peterson-Yantorno; M Coca-Prados; M M Civan
Journal: Am J Physiol Cell Physiol Date: 2000-08 Impact factor: 4.249

8. Adenosine stimulates Cl- channels of nonpigmented ciliary epithelial cells.

Authors: D A Carré; C H Mitchell; K Peterson-Yantorno; M Coca-Prados; M M Civan
Journal: Am J Physiol Date: 1997-10

9. Adenosine receptor activation modulates intraocular pressure in rabbits.

Authors: C E Crosson
Journal: J Pharmacol Exp Ther Date: 1995-04 Impact factor: 4.030

10. A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.

Authors: K A Jacobson; O Nikodijević; D Shi; C Gallo-Rodriguez; M E Olah; G L Stiles; J W Daly
Journal: FEBS Lett Date: 1993-12-20 Impact factor: 4.124

34 in total

1. Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.

Authors: Ang Li; Chi Ting Leung; Kim Peterson-Yantorno; Claire H Mitchell; Mortimer M Civan
Journal: Am J Physiol Cell Physiol Date: 2010-10-06 Impact factor: 4.249

A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse.

1. Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.

2. Reliable measurement of mouse intraocular pressure by a servo-null micropipette system.

3. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.

4. PD 116,948, a highly selective A1 adenosine receptor antagonist.

5. Ocular penetration of pilocarpine in primates.

6. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

7. Similarity of A(3)-adenosine and swelling-activated Cl(-) channels in nonpigmented ciliary epithelial cells.

8. Adenosine stimulates Cl- channels of nonpigmented ciliary epithelial cells.

9. Adenosine receptor activation modulates intraocular pressure in rabbits.

10. A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.

1. Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.

Review 2. Purinergic regulation of epithelial transport.

3. Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport.

Review 4. Basis of chloride transport in ciliary epithelium.

Review 5. Mechanisms of ATP release, the enabling step in purinergic dynamics.

6. Chapter 13. A₃ Adenosine Receptors.

Review 7. Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.

8. Cell-specific differential modulation of human trabecular meshwork cells by selective adenosine receptor agonists.

9. Electron probe X-ray microanalysis of intact pathway for human aqueous humor outflow.

10. Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species.