BACKGROUND: Dendritic cells (DC) are believed to be one of the first cell types infected during HIV transmission. Recently a single C-type lectin receptor (CLR), DC-SIGN, has been reported to be the predominant receptor on monocyte derived DC (MDDC) rather than CD4. The role of other CLRs in HIV binding and HIV binding by CLRs on other types of DC in vivo is largely unknown. OBJECTIVES AND STUDY DESIGN: Review HIV binding to DC populations, both in vitro and in vivo, in light of the immense interest of a recently re-identified CLR called DC-SIGN. RESULTS AND CONCLUSIONS: From recent work, it is clear that immature MDDC have a complex pattern of HIV gp120 binding. In contrast to other cell types gp120 has the potential to bind to several receptors on DC including CD4 and several types of C type lectin receptor, not just exclusively DC-SIGN. Given the diverse types of DC in vivo future work will need to focus on defining the receptors for HIV binding to these different cell types. Mucosal transmission of HIV in vivo targets immature sessile DCs, including Langerhans cells which lack DC-SIGN. The role of CLRs and DC-SIGN in such transmission remains to be defined.
BACKGROUND: Dendritic cells (DC) are believed to be one of the first cell types infected during HIV transmission. Recently a single C-type lectin receptor (CLR), DC-SIGN, has been reported to be the predominant receptor on monocyte derived DC (MDDC) rather than CD4. The role of other CLRs in HIV binding and HIV binding by CLRs on other types of DC in vivo is largely unknown. OBJECTIVES AND STUDY DESIGN: Review HIV binding to DC populations, both in vitro and in vivo, in light of the immense interest of a recently re-identified CLR called DC-SIGN. RESULTS AND CONCLUSIONS: From recent work, it is clear that immature MDDC have a complex pattern of HIV gp120 binding. In contrast to other cell types gp120 has the potential to bind to several receptors on DC including CD4 and several types of C type lectin receptor, not just exclusively DC-SIGN. Given the diverse types of DC in vivo future work will need to focus on defining the receptors for HIV binding to these different cell types. Mucosal transmission of HIV in vivo targets immature sessile DCs, including Langerhans cells which lack DC-SIGN. The role of CLRs and DC-SIGN in such transmission remains to be defined.
Authors: Andrew N Harman; Joey Lai; Stuart Turville; Shamith Samarajiwa; Lachlan Gray; Valerie Marsden; Sarah K Mercier; Sarah Mercier; Kate Jones; Najla Nasr; Arjun Rustagi; Helen Cumming; Heather Donaghy; Johnson Mak; Michael Gale; Melissa Churchill; Paul Hertzog; Anthony L Cunningham Journal: Blood Date: 2011-03-16 Impact factor: 22.113
Authors: Fedde Groot; Teunis B H Geijtenbeek; Rogier W Sanders; Christopher E Baldwin; Marta Sanchez-Hernandez; René Floris; Yvette van Kooyk; Esther C de Jong; Ben Berkhout Journal: J Virol Date: 2005-03 Impact factor: 5.103
Authors: Andrew N Harman; Marianne Kraus; Chris R Bye; Karen Byth; Stuart G Turville; Owen Tang; Sarah K Mercier; Najla Nasr; Josh L Stern; Barry Slobedman; Christoph Driessen; Anthony L Cunningham Journal: Blood Date: 2009-05-12 Impact factor: 22.113
Authors: Rogier W Sanders; Eelco van Anken; Alexei A Nabatov; I Marije Liscaljet; Ilja Bontjer; Dirk Eggink; Mark Melchers; Els Busser; Martijn M Dankers; Fedde Groot; Ineke Braakman; Ben Berkhout; William A Paxton Journal: Retrovirology Date: 2008-01-31 Impact factor: 4.602