Literature DB >> 11564572

Microchip-based systems for target validation and HTS.

S A. Sundberg1, A Chow, T Nikiforov, H G. Wada.   

Abstract

Microarray and microfluidic device technologies for performing genetic and biochemical analyses are revolutionizing biological research. These technologies are now being applied to gene expression profiling and to primary screening for target validation and lead discovery in the pharmaceutical industry. In this article, we briefly review microchip technology and discuss future development trends.

Entities:  

Year:  2000        PMID： 11564572     DOI： 10.1016/s1359-6446(00)00065-9

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  4 in total

1.  On-chip characterization of cryoprotective agent mixtures using an EWOD-based digital microfluidic device.

Authors:  Sinwook Park; Pavithra A L Wijethunga; Hyejin Moon; Bumsoo Han
Journal:  Lab Chip       Date:  2011-05-20       Impact factor: 6.799

2.  Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.

Authors:  Catherine Simpson; Nathaniel G Jones; Emily A Hull-Ryde; Dmitri Kireev; Michael Stashko; Keliang Tang; Jim Janetka; Scott A Wildman; William J Zuercher; Matthieu Schapira; Raymond Hui; William Janzen; L David Sibley
Journal:  ACS Infect Dis       Date:  2015-12-28       Impact factor: 5.084

3.  Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.

Authors:  Jessica E Hutti; Melissa A Porter; Adam W Cheely; Lewis C Cantley; Xiaodong Wang; Dmitri Kireev; Albert S Baldwin; William P Janzen
Journal:  PLoS One       Date:  2012-07-30       Impact factor: 3.240

4.  Hydrodynamic guiding for addressing subsets of immobilized cells and molecules in microfluidic systems.

Authors:  Thomas Brevig; Ulrich Krühne; Rachel A Kahn; Thomas Ahl; Michael Beyer; Lars H Pedersen
Journal:  BMC Biotechnol       Date:  2003-07-23       Impact factor: 2.563
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.