Literature DB >> 11564053

Target concentration intervention: beyond Y2K.

N H Holford1.   

Abstract

Target concentration intervention (TCI) is proposed as an alternative conceptual strategy to therapeutic drug monitoring (TDM). It is argued that the idea of a therapeutic range has limited the interpretation of measured drug concentrations and diminished the anticipated clinical benefit to patients by use of an oversimplified pharmacodynamic model. TCI on the other hand embraces pharmacokinetic and pharmacodynamic concepts and uses the idea of a target effect and associated target concentration to make rational individual dose decisions.

Entities:  

Mesh：

Year:  2001        PMID： 11564053      PMCID： PMC2014624          DOI： 10.1046/j.1365-2125.2001.0520s1055.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  14 in total

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2.  Therapeutic drug monitoring of antimicrobials.

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5.  A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics.

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6.  Influences of renal function descriptors on population pharmacokinetic modeling of vancomycin in Chinese adult patients.

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7.  The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine.

Authors:  Moustapha Hassan; Hatem Sallam; Zuzana Hassan
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8.  A Bayesian dose-individualization method for warfarin.

Authors:  Daniel F B Wright; Stephen B Duffull
Journal:  Clin Pharmacokinet       Date:  2013-01       Impact factor: 6.447

Review 9.  A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time.

Authors:  Paul K L Chin; Daniel F B Wright; David M Patterson; Matthew P Doogue; Evan J Begg
Journal:  Br J Clin Pharmacol       Date:  2014-09       Impact factor: 4.335

10.  Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial.

Authors:  Samir G Sakka; Anna K Glauner; Jürgen B Bulitta; Martina Kinzig-Schippers; Wolfgang Pfister; George L Drusano; Fritz Sörgel
Journal:  Antimicrob Agents Chemother       Date:  2007-07-09       Impact factor: 5.191
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