| Literature DB >> 11563125 |
T P Prakash1, A M Kawasaki, J F Johnston, M J Graham, T P Condon, M Manoharan.
Abstract
Antisense oligonucleotides with 2'-O-(2-[N,N-dimethyl)aminooxy]ethyl) or (2'-O-DMAOE) modification were synthesized and evaluated for nuclease resistance and pharmacology both in vitro and in vivo. This modification exhibits very high nuclease resistance and efficacy in various biological (ICAM-1, C-raf and PKC-alpha) targets.Entities:
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Year: 2001 PMID： 11563125 DOI： 10.1081/NCN-100002439
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381