Literature DB >> 11563123

Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?

D Rejman1, J Snásel, R Liboska, Z Tocík, O Paces, S Králíková, M Rinnová, P Kois, I Rosenberg.   

Abstract

Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.

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Year:  2001        PMID: 11563123     DOI: 10.1081/NCN-100002437

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  2 in total

1.  -CH2- lengthening of the internucleotide linkage in the ApA dimer can improve its conformational compatibility with its natural polynucleotide counterpart.

Authors:  J Hanus; I Barvík; K Ruszová-Chmelová; J Stepánek; P Y Turpin; J Bok; I Rosenberg; M Petrová-Endová
Journal:  Nucleic Acids Res       Date:  2001-12-15       Impact factor: 16.971

Review 2.  Synthetic Life with Alternative Nucleic Acids as Genetic Materials.

Authors:  Peng Nie; Yanfen Bai; Hui Mei
Journal:  Molecules       Date:  2020-07-31       Impact factor: 4.411

  2 in total

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