Literature DB >> 11563058

Properties of arabinonucleic acids (ANA & 20'F-ANA): implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA.

M J Damha1, A M Noronha, C J Wilds, J F Trempe, A Denisov, R T Pon, K Gehring.   

Abstract

Inversion of configuration of the C2' position of RNA leads to a very unique nucleic acid structure: arabinonucleic acid (ANA). ANA, and its 2'-fluoro derivative (2'F-ANA) from hybrids with RNA that are capable of activating RNase H, resulting in cleavage of the RNA strand. In this paper, we review the properties of duplexes formed between ANA (or 2'F-ANA) and its RNA complement. These studies support the notion that RNase H is sensitive to the minor groove dimensions of the hybrid substrate.

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Year:  2001        PMID： 11563058     DOI： 10.1081/NCN-100002317

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  6 in total

1.  Synthetic antisense oligodeoxynucleotides to transiently suppress different nucleus- and chloroplast-encoded proteins of higher plant chloroplasts.

Authors:  Emine Dinç; Szilvia Z Tóth; Gert Schansker; Ferhan Ayaydin; László Kovács; Dénes Dudits; Gyozo Garab; Sándor Bottka
Journal:  Plant Physiol       Date:  2011-10-06       Impact factor: 8.340

2.  2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing.

Authors:  A Kalota; L Karabon; C R Swider; E Viazovkina; M Elzagheid; M J Damha; A M Gewirtz
Journal:  Nucleic Acids Res       Date:  2006-01-18       Impact factor: 16.971

3.  Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy.

Authors:  Mayumi Takahashi; Haitang Li; Jiehua Zhou; Pritsana Chomchan; Veenu Aishwarya; Masad J Damha; John J Rossi
Journal:  Mol Ther Nucleic Acids       Date:  2019-07-11       Impact factor: 8.886

4.  A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice.

Authors:  Marylène Fortin; Hélène D'Anjou; Marie-Eve Higgins; Jasmine Gougeon; Paméla Aubé; Kamel Moktefi; Sonia Mouissi; Serge Séguin; Rosanne Séguin; Paolo M Renzi; Luc Paquet; Nicolay Ferrari
Journal:  Respir Res       Date:  2009-05-20

5.  Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA).

Authors:  Thomas Dowler; Denis Bergeron; Anna-Lisa Tedeschi; Luc Paquet; Nicolay Ferrari; Masad J Damha
Journal:  Nucleic Acids Res       Date:  2006-03-22       Impact factor: 16.971

6.  A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides.

Authors:  Seohyun Chris Kim; Lijun Zhou; Wen Zhang; Derek K O'Flaherty; Valeria Rondo-Brovetto; Jack W Szostak
Journal:  J Am Chem Soc       Date:  2020-01-22       Impact factor: 16.383
  6 in total

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