| Literature DB >> 11563055 |
S Gryaznov1, K Pongracz, T Matray, R Schultz, R Pruzan, J Aimi, A Chin, C Harley, B Shea-Herbert, J Shay, Y Oshima, A Asai, Y Yamashita.
Abstract
We have designed, synthesized, and evaluated using physical, chemical and biochemical assays various oligonucleotide N3'-->P5' phosphoramidates, as potential telomerase inhibitors. Among the prepared compounds were 2'-deoxy, 2'-hydroxy, 2'-methoxy, 2'-ribo-fluoro, and 2'-arabino-fluoro oligonucleotide phosphoramidates, as well as novel N3'-->P5' thio-phosphoramidates. The compounds demonstrated sequence specific and dose dependent activity with IC50 values in the sub-nM to pM concentration range.Entities:
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Year: 2001 PMID： 11563055 DOI： 10.1081/NCN-100002314
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381