| Literature DB >> 11563043 |
S Peyrottes1, N Schlienger, T Beltran, I Lefebvre, A Pompon, G Gosselin, A M Aubertin, J L Imbach, C Périgaud.
Abstract
Synthesis, biological activities and decomposition kinetics of novel phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-tButyl-2-thioethyl (tBuSATE) group and L-tyrosinyl residues are reported. All the derivatives appeared to be potent inhibitors of HIV-1 replication in various cell culture experiments. The proposed decomposition process of these mixed phosphotriesters may involve successively an esterase and then a phosphodiesterase activation.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11563043 DOI： 10.1081/NCN-100002302
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381