Literature DB >> 11563035

Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains.

F Seela1, N Ramzaeva, P Leonard, Y Chen, H Debelak, E Feiling, R Kröschel, M Zulauf, T Wenzel, T Fröhlich, M Kostrzewa.   

Abstract

The synthesis of phosphoramidites containing 7-deazaguanine, 7-deazaadenine, uracil and cytosine carrying aminopropargyl chains is described. The corresponding oligonucleotides are stabilized in duplexes thermally as well as against degradation by exonucleases.

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Year:  2001        PMID： 11563035     DOI： 10.1081/NCN-100002568

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  4 in total

1.  Propynyl groups in duplex DNA: stability of base pairs incorporating 7-substituted 8-aza-7-deazapurines or 5-substituted pyrimidines.

Authors:  Junlin He; Frank Seela
Journal:  Nucleic Acids Res       Date:  2002-12-15       Impact factor: 16.971

2.  Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA.

Authors:  Ewa A Kowal; Manjori Ganguly; Pradeep S Pallan; Luis A Marky; Barry Gold; Martin Egli; Michael P Stone
Journal:  J Phys Chem B       Date:  2011-11-08       Impact factor: 2.991

3.  RNA major groove modifications improve siRNA stability and biological activity.

Authors:  Montserrat Terrazas; Eric T Kool
Journal:  Nucleic Acids Res       Date:  2008-11-28       Impact factor: 16.971

4.  Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2'-deoxyuridines and their application in DNA triplex formation.

Authors:  John A Brazier; Takayuki Shibata; John Townsley; Brian F Taylor; Elaine Frary; Nicholas H Williams; David M Williams
Journal:  Nucleic Acids Res       Date:  2005-03-03       Impact factor: 16.971
  4 in total

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