Literature DB >> 11563011

Specific binding and stabilization of DNA and phosphorothioate DNA by amphiphilic alpha-helical peptides.

T Kubo1, M Fujii.   

Abstract

Synthetic cationic peptides with amphiphilic alpha-helical structure were found to have DNA binding ability to stabilize double and triple stranded DNA. The stabilization effect was significant for cationic alpha-helical peptides indicating the importance of an electrostatic interaction of a positive charge of peptides and a negative charge of DNAs.

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Year:  2001        PMID： 11563011     DOI： 10.1081/NCN-100002544

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  3 in total

1.  Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus.

Authors:  Roberto Lande; Dipyaman Ganguly; Valeria Facchinetti; Loredana Frasca; Curdin Conrad; Josh Gregorio; Stephan Meller; Georgios Chamilos; Rosalie Sebasigari; Valeria Riccieri; Roland Bassett; Hideki Amuro; Shirou Fukuhara; Tomoki Ito; Yong-Jun Liu; Michel Gilliet
Journal:  Sci Transl Med       Date:  2011-03-09       Impact factor: 17.956

2.  The nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs.

Authors:  Nagaraj M Gowda; Xianzhu Wu; D Channe Gowda
Journal:  PLoS One       Date:  2011-06-08       Impact factor: 3.240

Review 3.  Cell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases.

Authors:  Bhargavi Duvvuri; Christian Lood
Journal:  Front Immunol       Date:  2019-03-19       Impact factor: 7.561
  3 in total

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