Literature DB >> 11563004

Parallel DNA containing pyrazolo[3,4-D]pyrimidine analogues of isoguanine.

F Seela1, R Kröschel, Y He.   

Abstract

The phosphoramidites of 8-aza-7-deaza-2'-deoxyisoguanosine (1a) and its bromo derivative 1b as well as of 6-aza-2'-deoxyisocytidine and its 5-methyl derivative (3a,b) were synthesized. Parallel-stranded duplexes containing the nucleosides 1a,b show a significantly enhanced duplex stability compared to those containing 2'-deoxyisoguanosine.

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Year:  2001        PMID: 11563004     DOI: 10.1081/NCN-100002537

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  The base pairing properties of 8-aza-7-deaza-2'-deoxyisoguanosine and 7-halogenated derivatives in oligonucleotide duplexes with parallel and antiparallel chain orientation.

Authors:  Frank Seela; Rita Kröschel
Journal:  Nucleic Acids Res       Date:  2003-12-15       Impact factor: 16.971

  1 in total

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