| Literature DB >> 11562962 |
H Chapman1, M Kernan, J Rohloff, M Sparacino, T Terhorst.
Abstract
The diastereomers of GS-7171, aryl phosphoramidate derivatives of the anti-HIV nucleotide analog 9-[2-R-(phosphonomethoxy)propyl]adenine (tenofovir, PMPA), were isolated by batch elution chromatography and continuous simulated moving bed chromatography. The absolute configuration of the more pharmacologically active diastereomer, GS-7340, was determined to be (R,S,S) by single crystal x-ray crystallography.Entities:
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Year: 2001 PMID： 11562962 DOI： 10.1081/NCN-100002495
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381