Literature DB >> 11561708

Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins.

R J Nascimento1, J M Santana, S P Lozzi, C N Araújo, A R Teixeira.   

Abstract

The Triatoma infestans salivary gland proteins (TSGP) can induce local and systemic hypersensitivity reactions in humans. IgG antibodies against TSGP were present in higher levels in sera of Chagas disease patients, and in individuals living in triatomine-infested areas than in controls living in triatomine-free areas. TSGP-specific IgG1 was found in sera of Chagas patients, and of individuals living in triatomine-infested rural areas, and uniquely specific IgG4 was present in sera of Chagas patients living in triatomine-infested areas, reactive against TSGP. Unique specificities were not detected in sera of individuals reacting against the ubiquitous mosquito Culex quinquifasciatus saliva proteins (CSGP). In conclusion, IgG1 reactive against TSGP is the main antibody present in individuals living in the triatomine-infested study areas. Also, IgG4 is found in the sera of insect-transmitted Chagas disease patients living in study areas.

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Year:  2001        PMID: 11561708     DOI: 10.4269/ajtmh.2001.65.219

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   2.345


  23 in total

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Authors:  Joaquim X Sousa; Luis A Diaz; Donald P Eaton; Günter Hans-Filho; Elder Lanzani de Freitas; Livia Delgado; Ligia Maria F Ichimura; Flávia Cristaldi; Renata Orlandi; Norival Kesper; Eufrosina S Umezawa; Evandro A Rivitti; Valeria Aoki
Journal:  Am J Trop Med Hyg       Date:  2012-07-23       Impact factor: 2.345

2.  Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.

Authors:  Papa M Drame; Anne Poinsignon; Patrick Besnard; Jacques Le Mire; Maria A Dos-Santos; Cheikh S Sow; Sylvie Cornelie; Vincent Foumane; Jean-Claude Toto; Mbacké Sembene; Denis Boulanger; François Simondon; Filomeno Fortes; Pierre Carnevale; Franck Remoue
Journal:  Am J Trop Med Hyg       Date:  2010-07       Impact factor: 2.345

3.  Human antibody response to Aedes aegypti saliva in an urban population in Bolivia: a new biomarker of exposure to Dengue vector bites.

Authors:  Souleymane Doucoure; François Mouchet; Amandine Cournil; Gilbert Le Goff; Sylvie Cornelie; Yelin Roca; Mabel Guerra Giraldez; Zaira Barja Simon; Roxanna Loayza; Dorothée Misse; Jorge Vargas Flores; Annie Walter; Christophe Rogier; Jean Pierre Herve; Franck Remoue
Journal:  Am J Trop Med Hyg       Date:  2012-07-30       Impact factor: 2.345

4.  Immunogenic salivary proteins of Triatoma infestans: development of a recombinant antigen for the detection of low-level infestation of triatomines.

Authors:  Alexandra Schwarz; Stefan Helling; Nicolas Collin; Clarissa R Teixeira; Nora Medrano-Mercado; Jen C C Hume; Teresa C Assumpção; Katrin Marcus; Christian Stephan; Helmut E Meyer; José M C Ribeiro; Peter F Billingsley; Jesus G Valenzuela; Jeremy M Sternberg; Günter A Schaub
Journal:  PLoS Negl Trop Dis       Date:  2009-10-20

5.  Antibody responses of domestic animals to salivary antigens of Triatomainfestans as biomarkers for low-level infestation of triatomines.

Authors:  Alexandra Schwarz; Jeremy M Sternberg; Valerie Johnston; Nora Medrano-Mercado; Jennifer M Anderson; Jen C C Hume; Jesus G Valenzuela; Günter A Schaub; Peter F Billingsley
Journal:  Int J Parasitol       Date:  2009-02-25       Impact factor: 3.981

6.  First attempt to validate human IgG antibody response to Nterm-34kDa salivary peptide as biomarker for evaluating exposure to Aedes aegypti bites.

Authors:  Emmanuel Elanga Ndille; Souleymane Doucoure; Georgia Damien; François Mouchet; Papa Makhtar Drame; Sylvie Cornelie; Herbert Noukpo; Sandra Yamadjako; Armel Djenontin; Nicolas Moiroux; Dorothee Misse; Martin Akogbeto; Vincent Corbel; Marie-Claire Henry; Fabrice Chandre; Thierry Baldet; Franck Remoue
Journal:  PLoS Negl Trop Dis       Date:  2012-11-15

7.  IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal.

Authors:  Papa M Drame; Vanessa Machault; Abdoulaye Diallo; Sylvie Cornélie; Anne Poinsignon; Richard Lalou; Mbacké Sembène; Stéphanie Dos Santos; Christophe Rogier; Frédéric Pagès; Jean-Yves Le Hesran; Franck Remoué
Journal:  Malar J       Date:  2012-03-16       Impact factor: 2.979

8.  Humoral response to the Anopheles gambiae salivary protein gSG6: a serological indicator of exposure to Afrotropical malaria vectors.

Authors:  Cinzia Rizzo; Raffaele Ronca; Gabriella Fiorentino; Federica Verra; Valentina Mangano; Anne Poinsignon; Sodiomon Bienvenu Sirima; Issa Nèbiè; Fabrizio Lombardo; Franck Remoue; Mario Coluzzi; Vincenzo Petrarca; David Modiano; Bruno Arcà
Journal:  PLoS One       Date:  2011-03-17       Impact factor: 3.240

9.  Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites.

Authors:  Anne Poinsignon; Sylvie Cornelie; Fatou Ba; Denis Boulanger; Cheikh Sow; Marie Rossignol; Cheikh Sokhna; Badara Cisse; François Simondon; Franck Remoue
Journal:  Malar J       Date:  2009-08-13       Impact factor: 2.979

10.  gSG6-P1 salivary biomarker discriminates micro-geographical heterogeneity of human exposure to Anopheles bites in low and seasonal malaria areas.

Authors:  André Barembaye Sagna; Jean Biram Sarr; Lobna Gaayeb; Papa Makhtar Drame; Mamadou Ousmane Ndiath; Simon Senghor; Cheikh Saya Sow; Anne Poinsignon; Modou Seck; Emmanuel Hermann; Anne-Marie Schacht; Ngor Faye; Cheikh Sokhna; Franck Remoue; Gilles Riveau
Journal:  Parasit Vectors       Date:  2013-03-15       Impact factor: 3.876

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